FEATURES

DESCRIPTION

Also known as FBX32_HUMAN, FBXO32. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBXO32

F-box only protein 32

FBXO32

Molecular Synopsis