FEATURES

FAMILY

DESCRIPTION

Also known as TET5B_HUMAN, TENT5B, FAM46B. Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner (PubMed:32009146, PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (PubMed:32009146). Prefers RNA molecules that are adenosine-rich close to 3'-end (PubMed:32009146). In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 (PubMed:30532005).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TENT5B

Terminal nucleotidyltransferase 5B

TENT5B

Molecular Synopsis