FEATURES

FAMILY

organo anion transporter (TC 2.A.60) family

DESCRIPTION

Also known as SO4A1_HUMAN, SLCO4A1, OATP1, OATP4A1, OATPE, SLC21A12. Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrierr (Probable).

Also known as SO4A1_HUMAN, SLCO4A1, OATP1, OATP4A1, OATPE, SLC21A12. Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxi ...

EXTERNAL LINKS

SLCO4A1

Solute carrier organic anion transporter family member 4A1

SLCO4A1

Molecular Synopsis