FEATURES

FAMILY

DESCRIPTION

Also known as SARAF_HUMAN, SARAF, TMEM66, XTP3. Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SARAF

Store-operated calcium entry-associated regulatory factor

SARAF

Molecular Synopsis