FEATURES

FAMILY

DESCRIPTION

Also known as MTBP_HUMAN, MTBP. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Interacts with MDM2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTBP

Mdm2-binding protein

MTBP

Molecular Synopsis