FEATURES

DESCRIPTION

Also known as KLRG1_HUMAN, KLRG1, CLEC15A, MAFA, MAFAL. Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KLRG1

Killer cell lectin-like receptor subfamily G member 1

KLRG1

Molecular Synopsis