FEATURES

FAMILY

DESCRIPTION

Also known as MTMR8_HUMAN, MTMR8. Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3, 5-bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). Homodimer (PubMed:26143924). Heterodimer with MTMR9 (PubMed:16787938, PubMed:22647598).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTMR8

Myotubularin-related protein 8

MTMR8

Molecular Synopsis