FEATURES

FAMILY

DESCRIPTION

Also known as STALP_HUMAN, STAMBPL1, AMSHLP, KIAA1373. Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

STAMBPL1

AMSH-like protease

STAMBPL1

Molecular Synopsis