FEATURES

FAMILY

DESCRIPTION

Also known as CELF6_HUMAN, CELF6, BRUNOL6. RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CELF6

CUGBP Elav-like family member 6

CELF6

Molecular Synopsis