FEATURES

DESCRIPTION

Also known as ZN462_HUMAN, ZNF462, KIAA1803. Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). Interacts with PBX1; this interaction prevents PBX1-HOXA9 heterodimer from forming and binding to DNA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZNF462

Zinc finger protein 462

ZNF462

Molecular Synopsis