FEATURES

FAMILY

DESCRIPTION

Also known as MRGX1_HUMAN, MRGPRX1, MRGX1, SNSR3, SNSR4. Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Also known as MRGX1_HUMAN, MRGPRX1, MRGX1, SNSR3, SNSR4. Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including ...

EXTERNAL LINKS

MRGPRX1

Mas-related G-protein coupled receptor member X1

MRGPRX1

Molecular Synopsis