FEATURES

FAMILY

DESCRIPTION

Also known as IFT74_HUMAN, IFT74, CCDC2, CMG1. Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium (PubMed:23990561). Binds beta-tubulin via its basic region (PubMed:23990561). Required for ciliogenesis (PubMed:23990561). Essential for flagellogenesis during spermatogenesis (PubMed:33689014). Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:23990561, PubMed:33531668). Interacts with IFT81; the interaction is direct (PubMed:15955805, PubMed:23990561, PubMed:33531668). Within the IFT complex B, IFT74 and IFT81 mediate the transport of tubulin within the cilium (PubMed:15955805, PubMed:23990561). Interacts (via basic region) with beta-tubulin (via acidic region); interaction is direct (PubMed:23990561). Interacts with ARL13B and IFT88 (PubMed:24339792). Interacts (via the IFT74/IFT81 heterodimer) with RABL2B (PubMed:28428259, PubMed:28625565). Interacts with IFT57 and TTC30B (By similarity).

EXTERNAL LINKS

IFT74

Intraflagellar transport protein 74 homolog

IFT74

Molecular Synopsis