FEATURES

FAMILY

DESCRIPTION

Also known as PRIC1_HUMAN, PRICKLE1, RILP. Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Interacts with REST.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PRICKLE1

Prickle-like protein 1

PRICKLE1

Molecular Synopsis