FEATURES

FAMILY

DESCRIPTION

Also known as ATAD5_HUMAN, ATAD5, C17orf41, Elg1, FRAG1. Has an imporant role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis (PubMed:15983387). Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis (PubMed:15983387). Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway (PubMed:20147293). As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle (PubMed:23277426, PubMed:23937667). This seems to be dependent on its ATPase activity (PubMed:23277426). Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner (PubMed:31844045). Ultimately this enables replication fork regression, breakage, and eventual fork restart (PubMed:31844045). Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks (PubMed:31844045). Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks (PubMed:31844045). Component of a heteropentameric replication factor ATAD5 RFC-like complex composed of one large subunit (ATAD5) and four small subunits (RFC2, RFC3, RFC4 and RFC5) (PubMed:13678589, PubMed:20147293, PubMed:23277426). Within the ATAD5 RFC-like complex, interacts with RFC2, RFC4 and RFC5 (PubMed:13678589, PubMed:20147293, PubMed:23277426, PubMed:31844045). Within the ATAD5 RFC-like complex, interacts directly via-N terminal with RAD51; the interactions is enhanced under replication stress (PubMed:31844045). Interacts with RB1 predominantly in G1 phase via its LXCXE motif (By similarity). Interacts with RAD9A in growing cells (PubMed:15983387). The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents (PubMed:15983387). Interacts with BRD4 (PubMed:21555454). Interacts with PCNA (PubMed:20147293, PubMed:23277426). Interacts with deubiquitinating enzyme USP1, and its associated factor, WDR48 (PubMed:20147293, PubMed:31844045).

Also known as ATAD5_HUMAN, ATAD5, C17orf41, Elg1, FRAG1. Has an imporant role in DNA replication and in maintaining genome integrity during replication stress (PubMed:15983387, PubMed:19755857). ...

EXTERNAL LINKS

ATAD5

ATPase family AAA domain-containing protein 5

ATAD5

Molecular Synopsis