FEATURES

FAMILY

DESCRIPTION

Also known as HS3S6_HUMAN, HS3ST6, HS3ST5. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HS3ST6

Heparan sulfate glucosamine 3-O-sulfotransferase 6

HS3ST6

Molecular Synopsis