FEATURES

DESCRIPTION

Also known as MCCA_HUMAN, MCCC1, MCCA. Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Probably a dodecamer composed of six biotin-containing alpha subunits (MCCC1) and six beta (MCCC2) subunits (PubMed:17360195). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MCCC1

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

MCCC1

Molecular Synopsis