FEATURES

DESCRIPTION

Also known as PNKP_HUMAN, PNKP. Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193). Monomer (By similarity). Interacts (via FHA domain) with XRCC4; mainly interacts with XRCC4 phosphorylated by CK2 but is also able to interact at much lower level with unphosphorylated PNKP (PubMed:15385968, PubMed:20852255, PubMed:28453785).

EXTERNAL LINKS

PNKP

Bifunctional polynucleotide phosphatase/kinase

PNKP

Molecular Synopsis