FEATURES

DESCRIPTION

Also known as ASCL2_HUMAN, ASCL2, BHLHA45, HASH2. AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Efficient DNA binding requires dimerization with another bHLH protein. Interacts with SETD1A. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ASCL2

Achaete-scute homolog 2

ASCL2

Molecular Synopsis