FEATURES

FAMILY

DESCRIPTION

Also known as SLX1_HUMAN, SLX1A, SLX1B, GIYD1, SLX1, GIYD2, SLX1. Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Forms a heterodimer with SLX4.

Also known as SLX1_HUMAN, SLX1A, SLX1B, GIYD1, SLX1, GIYD2, SLX1. Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA re ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLX1A, SLX1B

Structure-specific endonuclease subunit SLX1

SLX1A, SLX1B

Molecular Synopsis