FEATURES

DESCRIPTION

Also known as RHNO1_HUMAN, RHNO1, C12orf32, RHINO. Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. Interacts with RAD9A, RAD18, TOPBP1 and UBE2N.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RHNO1

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

RHNO1

Molecular Synopsis