FEATURES

DESCRIPTION

Also known as MTA3_HUMAN, MTA3, KIAA1266. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12705869, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:33283408, PubMed:12705869, PubMed:15454082, PubMed:28977666, PubMed:16428440). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:28977666, PubMed:16428440). Interacts with BCL6 (PubMed:15454082). Interacts with NACC2 (PubMed:22926524). Interacts with PWWP2B (By similarity).

EXTERNAL LINKS

MTA3

Metastasis-associated protein MTA3

MTA3

Molecular Synopsis