FEATURES

DESCRIPTION

Also known as SPNDC_HUMAN, SPINDOC, C11orf84. Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability (PubMed:29061846). Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway (PubMed:29061846). Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). Interacts with SPIN1, SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Interacts with TCF7L2 in a SPIN1-dependent manner (PubMed:29061846). Interacts with PARP1; promoting PARP1 ADP-ribosyltransferase activity (PubMed:34737271).

EXTERNAL LINKS

SPINDOC

Spindlin interactor and repressor of chromatin-binding protein

SPINDOC

Molecular Synopsis