FEATURES

DESCRIPTION

Also known as CRUM3_HUMAN, CRB3. Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). Component of a complex composed of CRB3, PALS1 and PATJ (By similarity). Interacts (via C-terminus) with PALS1 (via PDZ domain) (PubMed:12527193, PubMed:12771187). Interacts with PARD6A (PubMed:14718572). Interacts (via intracellular domain) with EPB41L5 (PubMed:17920587).

EXTERNAL LINKS

CRB3

Protein crumbs homolog 3

CRB3

Molecular Synopsis