FEATURES

FAMILY

DESCRIPTION

Also known as EDEM2_HUMAN, EDEM2, C20orf31, C20orf49. Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EDEM2

ER degradation-enhancing alpha-mannosidase-like protein 2

EDEM2

Molecular Synopsis