FEATURES

FAMILY

DESCRIPTION

Also known as ALG8_HUMAN, ALG8. Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ALG8

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1, 3-glucosyltransferase

ALG8

Molecular Synopsis