FEATURES

FAMILY

DESCRIPTION

Also known as TALD3_HUMAN, KIAA0586, TALPID3. Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). Interacts with CCP110, CEP290, CEP97, KIF24.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KIAA0586

Protein TALPID3

KIAA0586

Molecular Synopsis