FEATURES

DESCRIPTION

Also known as CAR10_HUMAN, CARD10, CARMA3. Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity). Interacts with TMEM43; this interaction is essential for EGFR-mediated NF-kappa-B activation (PubMed:27991920).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CARD10

Caspase recruitment domain-containing protein 10

CARD10

Molecular Synopsis