FEATURES

DESCRIPTION

Also known as TRPM6_HUMAN, TRPM6, CHAK2. Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Interacts (via kinase domain) with RACK1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRPM6

Transient receptor potential cation channel subfamily M member 6

TRPM6

Molecular Synopsis