FEATURES

DESCRIPTION

Also known as IKBZ_HUMAN, NFKBIZ, IKBZ, INAP, MAIL. Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645). Seems also to activate NF-kappa-B-mediated transcription (PubMed:16622025). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025). Promotes transcription of LCN2 and DEFB4 (PubMed:16622025). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). Interacts with NFKB1/p50 (PubMed:16513645). Interacts with RELA (PubMed:16513645). Interacts with AKIRIN2 (By similarity).

Also known as IKBZ_HUMAN, NFKBIZ, IKBZ, INAP, MAIL. Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025). Inhibits NF-kappa-B activity without af ...

EXTERNAL LINKS

NFKBIZ

NF-kappa-B inhibitor zeta

NFKBIZ

Molecular Synopsis