FEATURES

FAMILY

DESCRIPTION

Also known as BCDO2_HUMAN, BCO2, BCDO2. Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9, 10 and the 9', 10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BCO2

Carotenoid-cleaving dioxygenase, mitochondrial

BCO2

Molecular Synopsis