FEATURES

FAMILY

pterin-4-alpha-carbinolamine dehydratase family

DESCRIPTION

Also known as PHS2_HUMAN, PCBD2, DCOH2, DCOHM. Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity)., Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity. Homotetramer. Interacts with DYRK1B.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PCBD2

Pterin-4-alpha-carbinolamine dehydratase 2

PCBD2

Molecular Synopsis