FEATURES

FAMILY

DESCRIPTION

Also known as PTN23_HUMAN, PTPN23, KIAA1471. Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). Interacts with GRAP2 and GRB2 (PubMed:21179510). Interacts with UBAP1 (PubMed:21757351, PubMed:27839950). Interacts with CHMP4B (PubMed:18434552).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTPN23

Tyrosine-protein phosphatase non-receptor type 23

PTPN23

Molecular Synopsis