FEATURES

FAMILY

DESCRIPTION

Also known as RPA2_HUMAN, POLR1B. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

POLR1B

DNA-directed RNA polymerase I subunit RPA2

POLR1B

Molecular Synopsis