FEATURES

FAMILY

DESCRIPTION

Also known as PA2H2_BOTMO, PA2H2. Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity. Shows high myotoxin activities (PubMed:16442348, PubMed:9637370, PubMed:31748642). Also shows neurotoxicity, since it induces muscle paralysis when tested on mouse phrenic-diaphragm preparations (PubMed:16442348, PubMed:23810946, PubMed:26457430, PubMed:30679550). Displays edema-inducing activities (PubMed:9637370, PubMed:16442348, PubMed:26457430). Also displays antimicrobial activity against E.coli and C.albicans, as well as antitumoral activity against some human and mice cell lines (PubMed:16442348). In addition, it is effective as parasiticidal agent against Leishmania sp. and S.mansoni (PubMed:16442348). It also disrupts negatively charged liposomes in a dose- and temperature-dependent manner and shows toxicity by intraperitoneal route (PubMed:16442348). In contrast to other phospholipase A2-like toxins, this myotoxin does not require fatty acid binding to be active (PubMed:29287778). Homodimer; non-covalently linked (probable alternative/compact dimer conformation) (Ref.4, PubMed:26457430, PubMed:29287778, PubMed:30679550).

EXTERNAL LINKS

PA2H2

Mutations

Mutation(s) distribution

Mutations table