FEATURES

FAMILY

DESCRIPTION

Also known as S40A1_HUMAN, SLC40A1, FPN1, IREG1, SLC11A3. Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Identified in a complex with STOM (PubMed:23219802). Interacts with HAMP; this interaction promotes SLC40A1 rapid ubiquitination (PubMed:22682227, PubMed:29237594).

Also known as S40A1_HUMAN, SLC40A1, FPN1, IREG1, SLC11A3. Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15 ...

EXTERNAL LINKS

SLC40A1

Solute carrier family 40 member 1

SLC40A1

Molecular Synopsis