FEATURES

FAMILY

DESCRIPTION

Also known as DUS2L_HUMAN, DUS2, DUS2L. Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). Interacts with EPRS1. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DUS2

tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

DUS2

Molecular Synopsis