FEATURES

FAMILY

DESCRIPTION

Also known as PI4KB_HUMAN, PI4KB, PIK4CB. Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1, 4, 5, -trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity)., (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622)., (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (PubMed:17555535). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3 (PubMed:23572552, PubMed:27009356, PubMed:27989622, PubMed:22124328, PubMed:22258260). Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (PubMed:23572552). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (PubMed:28289207). Interacts with ATG9A (PubMed:30917996).

EXTERNAL LINKS

PI4KB

Phosphatidylinositol 4-kinase beta

PI4KB

Molecular Synopsis