FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE10_HUMAN, PDE10A. Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:27058447, PubMed:17389385). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:27058447, PubMed:17389385). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDE10A

cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10A

PDE10A

Molecular Synopsis