FEATURES

FAMILY

DESCRIPTION

Also known as UCHL5_HUMAN, UCHL5, UCH37. Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UCHL5

Ubiquitin carboxyl-terminal hydrolase isozyme L5

UCHL5

Molecular Synopsis