FEATURES

FAMILY

DESCRIPTION

Also known as M3K4_HUMAN, MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1. Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (PubMed:12052864). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (PubMed:20221403). Interacts with CDC42 (By similarity).

Also known as M3K4_HUMAN, MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1. Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK path ...

EXTERNAL LINKS

MAP3K4

Mitogen-activated protein kinase kinase kinase 4

MAP3K4

Molecular Synopsis