FEATURES

FAMILY

DESCRIPTION

Also known as NPC1_HUMAN, NPC1. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:10821832, PubMed:12554680, PubMed:18772377, PubMed:27238017, PubMed:9211849, PubMed:9927649). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:27378690, PubMed:28784760, PubMed:9211849, PubMed:9927649). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9 (PubMed:28336668)., (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. Interacts (via the second lumenal domain) with NPC2 (PubMed:18772377, PubMed:27238017, PubMed:27551080). Interacts with TMEM97; the interaction may decrease NPC1 availability to the cell (PubMed:19583955, PubMed:34799735). Interacts with TIM1 (PubMed:25855742). Interacts with SLC38A9; this interaction inhibits cholesterol-mediated mTORC1 activation via its sterol transport activity (PubMed:28336668).

EXTERNAL LINKS

NPC1

NPC intracellular cholesterol transporter 1

Structural Ligandability

Domains Chains

0 chains assessed

9 chains not associated with a domain

NPC1

Structural Ligandability

Domains Chains

Distribution