FEATURES

DESCRIPTION

Also known as PRG2_HUMAN, PRG2, MBP. Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PRG2

Bone marrow proteoglycan

Evidence from Cancer Cell Lines

Data retrieved from DepMap at the Broad Institute .

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