FEATURES

FAMILY

DESCRIPTION

Also known as SPIKE_CVHNL, S. S1 region attaches the virion to the cell membrane by interacting with host ACE2, initiating the infection (PubMed:15897467, PubMed:29142129, PubMed:19901337). Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Homotrimer. During virus morphogenesis, found in a complex with M proteins (By similarity). Interacts with host ACE2(PubMed:15897467).

EXTERNAL LINKS

S

Spike glycoprotein

S

Molecular Synopsis