FEATURES

DESCRIPTION

Also known as SAS6_HUMAN, SASS6, SAS6. Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853). Nine homodimers form a cartwheel structure with an internal diameter of 23 nm and radial spokes connecting to the microtubule triplets (By similarity). Forms a complex with CENPJ and STIL (PubMed:22020124). Interacts with FBXW5 (PubMed:21725316). Interacts with NUP62 and TUBG1 at the centrosome (PubMed:24107630). Interacts with CENATAC; the interaction increases with CENATAC acetylation (PubMed:31722219). Interacts with FZR1; the interaction is regulated by CENATAC and leads to SASS6 proteasomal degradation (PubMed:31722219).

EXTERNAL LINKS

SASS6

Spindle assembly abnormal protein 6 homolog

SASS6

Molecular Synopsis