FEATURES

FAMILY

DESCRIPTION

Also known as HS2ST_HUMAN, HS2ST1, HS2ST, KIAA0448. Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Homotrimer. Interacts with the C5-epimerase GLCE (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HS2ST1

Heparan sulfate 2-O-sulfotransferase 1

HS2ST1

Molecular Synopsis