FEATURES

FAMILY

DESCRIPTION

Also known as TRM61_HUMAN, TRMT61A, C14orf172, TRM61. Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRMT61A

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

TRMT61A

Molecular Synopsis