FEATURES

FAMILY

class V-like SAM-binding methyltransferase superfamily

DESCRIPTION

Also known as NSD1_HUMAN, NSD1, ARA267, KMT3B. Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand. Interacts with ZNF496 (By similarity). Interacts with AR DNA- and ligand-binding domains.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NSD1

Histone-lysine N-methyltransferase, H3 lysine-36 specific

NSD1

Molecular Synopsis