FEATURES

FAMILY

DESCRIPTION

Also known as CBPC4_HUMAN, AGBL1, CCP4. Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Interacts with MYLK (By similarity). Interacts with TCF4 (PubMed:24094747).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AGBL1

Cytosolic carboxypeptidase 4

AGBL1

Molecular Synopsis