FEATURES

FAMILY

DESCRIPTION

Also known as CLK1_HUMAN, CLK1, CLK. Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). Interacts with PPIG and UBL5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLK1

Dual specificity protein kinase CLK1

CLK1

Molecular Synopsis